Welcome to ITPain

We harmonise preclinical and clinical protocols for chronic pain research to accelerate translational biomarker discovery and improve patient outcomes.

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  1. We will compare study protocols/CRFs from previous preclinical and clinical studies related to chronic neuropathic, musculoskeletal, visceral, pelvic, and postsurgical pain generated within several consortia in which network members have been involved.
  2. We will start developing a server infrastructure to share large data sets from previous studies and to unify currently available data (and data assessed in future chronic pain trials) related to chronic pain, which will lead to best practice for data handling and sharing
  3. We will analyse existing datasets from previous studies to assess the comparability and integrability of several datasets (e.g., CRF, PROMs from clinical and behavioural readouts from preclinical studies, *omics data), which will allow to identify translational biomarkers for chronic pain across preclinical and clinical studies (and pain aetiologies) in the future.
  4. We will design recommendations on harmonisation of study protocols related to animal pain research and human pain trials based on data analysis in literature searches and discussions between all stakeholders (including researchers, clinical scientists, clinicians, data analysts), patients, and pain societies by finding a valuable consensus
NeuroERAnet Figure 4 - Translational pain research framework

Project Overview

The ITPain project aims to harmonize protocols for chronic pain research across preclinical and clinical studies. By standardizing approaches and data collection methods, we can improve translational research and accelerate the development of new treatments for chronic pain conditions.

Key Objectives